Transparency · CHAI Applied Model Card
Anemia
CHAI Applied Model Card (v0.1) for the Anemia pattern in Zenlo Labs. This document is not CHAI-certified or CHAI-endorsed.
Header
Summary
The Anemia pattern flags low hemoglobin, hematocrit, and/or microcytic indices in adult complete blood count panels, signaling potential anemia for physician review. Deterministic rules compare hemoglobin and hematocrit against sex-aware reference lower limits and evaluate mean corpuscular volume for microcytosis patterns. Claude Haiku 4.5 provides narrative context on which CBC indices triggered the flag. For licensed functional-medicine physicians, this is supportive clinical decision support — it does not classify anemia subtype (iron deficiency vs. B12 vs. hemolytic), assess bleeding sources, or replace hematology referral. The pattern prompts correlation with iron studies, B12/folate, reticulocyte count, and clinical symptoms.
Uses & Directions
Intended use
Clinical decision support for licensed physicians reviewing CBC indices suggestive of anemia in adult panels.
Primary users
Licensed functional-medicine physicians and similarly qualified clinicians.
How to use
Correlate flagged CBC values with iron studies, B12/folate, reticulocytes, and bleeding history.
Target population
Adults aged 18 and older in the United States.
Out of scope
- Direct patient use without physician oversight
- Pediatric anemia evaluation
- Standalone diagnosis of anemia etiology
- Hemoglobinopathy or thalassemia genotyping
Warnings
Clinical risk level
Low — supportive tool; the treating physician retains full clinical judgment and responsibility.
Known limitations
- Low hemoglobin has many etiologies beyond iron deficiency.
- Does not incorporate reticulocyte count or peripheral smear review.
- Acute blood loss may not be captured in a single CBC time point.
Validation note
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Trust Ingredients
AI system facts
- Deterministic pattern detector (anemia) plus Claude Haiku 4.5 for narrative synthesis
- Primary inputs: Hemoglobin, hematocrit, and MCV with sex-aware reference comparison.
- Output: Pattern flag plus narrative on CBC abnormalities suggestive of anemia.
Security & compliance
- Anthropic Business Associate Agreement with zero-data-retention configuration
- HIPAA-aligned design; no patient data used for model training
Ongoing maintenance
Versioned, transparent, and reproducible via a public independent audit harness (see Resources).
Transparency
Self-funded development; no third-party sponsor for this pattern card.
Key Metrics
Usefulness / Efficacy
Zenlo’s detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern. Source: 5-model benchmark, medRxiv MEDRXIV/2026/346284.
Fairness / Equity
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Safety / Reliability
- Supportive-only; not intended as a standalone diagnostic
- Physician authorization required before clinical use
- Deterministic detector is reproducible for inputs: HGB, HCT, MCV
Resources
- medRxiv preprint MEDRXIV/2026/346284 — 5-model benchmark (system-level detector evaluation)
- JAMIA Open submission JAMIO-2026-0120 (under review)
- Independent audit harness: github.com/dimashibakov/zenlo-audit — reproducibility manifest, NHANES 2015–2016 cycle, harness commit c10afe8
Note: The mention or sharing of any examples, products, organizations, or individuals does not indicate any endorsement by the Coalition for Health AI (CHAI). Zenlo Labs is a clinical decision support tool intended exclusively for use by licensed healthcare providers — not a substitute for professional medical judgment, and not intended for direct patient use.