Transparency · CHAI Applied Model Card
Cardiovascular Risk
CHAI Applied Model Card (v0.1) for the Cardiovascular Risk pattern in Zenlo Labs. This document is not CHAI-certified or CHAI-endorsed.
Header
Summary
The Cardiovascular Risk pattern flags basic lipid and inflammatory markers associated with atherosclerotic cardiovascular disease in adult laboratory panels. A deterministic detector evaluates LDL cholesterol, HDL cholesterol, triglycerides, and high-sensitivity CRP against established threshold rules; any qualifying abnormality fires the pattern. Claude Haiku 4.5 synthesizes a physician-facing narrative that places flagged markers in clinical context. The pattern is supportive clinical decision support for licensed functional-medicine physicians — it highlights combinations of lipid and inflammatory signals for review, not a standalone cardiac diagnosis. Advanced markers such as ApoB and Lp(a) are handled by the separate Advanced Cardiovascular Risk pattern.
Uses & Directions
Intended use
Clinical decision support for licensed physicians reviewing basic lipid and inflammatory cardiovascular risk markers in adult panels.
Primary users
Licensed functional-medicine physicians and similarly qualified clinicians.
How to use
Review flagged output with the full clinical picture, family history, blood pressure, and imaging or risk scores as appropriate. Physician authorization is required before clinical use.
Target population
Adults aged 18 and older in the United States.
Out of scope
- Direct patient use without physician oversight
- Pediatric populations
- Standalone diagnosis or treatment decisions
- Replacement for formal cardiovascular risk calculators or stress testing
Warnings
Clinical risk level
Low — supportive tool; the treating physician retains full clinical judgment and responsibility.
Known limitations
- Uses basic lipid and hs-CRP thresholds; does not incorporate ApoB, Lp(a), or advanced lipoprotein subfractions.
- Does not assess blood pressure, smoking, or family history — essential components of full cardiovascular risk assessment.
- Thresholds may not reflect patient-specific targets from specialty guidelines.
Validation note
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Trust Ingredients
AI system facts
- Deterministic pattern detector (cardiovascular_risk) plus Claude Haiku 4.5 for narrative synthesis
- Primary inputs: LDL, HDL, triglycerides, and hs-CRP from structured laboratory extraction, with sex-aware HDL thresholds where applicable.
- Output: Pattern flag plus narrative explanation of which cardiovascular markers triggered review.
Security & compliance
- Anthropic Business Associate Agreement with zero-data-retention configuration
- HIPAA-aligned design; no patient data used for model training
Ongoing maintenance
Versioned, transparent, and reproducible via a public independent audit harness (see Resources).
Transparency
Self-funded development; no third-party sponsor for this pattern card.
Key Metrics
Usefulness / Efficacy
Zenlo’s detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern. Source: 5-model benchmark, medRxiv MEDRXIV/2026/346284.
Fairness / Equity
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Safety / Reliability
- Supportive-only; not intended as a standalone diagnostic
- Physician authorization required before clinical use
- Deterministic detector is reproducible for inputs: LDL, HDL, TG, HSCRP
Resources
- medRxiv preprint MEDRXIV/2026/346284 — 5-model benchmark (system-level detector evaluation)
- JAMIA Open submission JAMIO-2026-0120 (under review)
- Independent audit harness: github.com/dimashibakov/zenlo-audit — reproducibility manifest, NHANES 2015–2016 cycle, harness commit c10afe8
Note: The mention or sharing of any examples, products, organizations, or individuals does not indicate any endorsement by the Coalition for Health AI (CHAI). Zenlo Labs is a clinical decision support tool intended exclusively for use by licensed healthcare providers — not a substitute for professional medical judgment, and not intended for direct patient use.