Transparency · CHAI Applied Model Card

Inflammation

CHAI Applied Model Card (v0.1) for the Inflammation pattern in Zenlo Labs. This document is not CHAI-certified or CHAI-endorsed.

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Summary

The Inflammation pattern surfaces laboratory evidence of systemic or chronic inflammatory activity in adult panels. A deterministic detector evaluates high-sensitivity CRP, erythrocyte sedimentation rate, and ferritin against pattern-specific thresholds, with sex-aware ferritin cutoffs. Any qualifying elevation fires the pattern. An LLM-assisted narrative explains which inflammatory markers are abnormal and suggests clinical context for physician review. The tool is intended for licensed functional-medicine physicians as supportive clinical decision support — it does not distinguish infection from autoimmune or metabolic inflammation, and it does not replace targeted workup. Outputs prompt physician judgment rather than automated diagnosis.

Uses & Directions

Intended use

Clinical decision support for licensed physicians evaluating inflammatory marker patterns in adult laboratory panels.

Primary users

Licensed functional-medicine physicians and similarly qualified clinicians.

How to use

Interpret flagged results alongside symptoms, medications, acute illness, and follow-up inflammatory or autoimmune testing. Physician authorization required.

Target population

Adults aged 18 and older in the United States.

Out of scope

• Direct patient use without physician oversight
• Pediatric populations
• Standalone diagnosis of specific inflammatory diseases
• Acute infection triage without clinical correlation

Warnings

Clinical risk level

Low — supportive tool; the treating physician retains full clinical judgment and responsibility.

Known limitations

• hs-CRP and ferritin are non-specific; elevations have many causes including infection, obesity, and liver disease.
• Does not differentiate acute versus chronic inflammation.
• Ferritin as an inflammatory marker overlaps semantically with iron-status interpretation.

Validation note

Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.

Trust Ingredients

AI system facts

• Deterministic pattern detector (inflammation) plus Claude Haiku 4.5 for narrative synthesis
• Primary inputs: hs-CRP, ESR, and ferritin from structured laboratory extraction.
• Output: Pattern flag plus narrative on inflammatory marker abnormalities.

Security & compliance

• Anthropic Business Associate Agreement with zero-data-retention configuration
• HIPAA-aligned design; no patient data used for model training

Ongoing maintenance

Versioned, transparent, and reproducible via a public independent audit harness (see Resources).

Transparency

Self-funded development; no third-party sponsor for this pattern card.

Key Metrics

Usefulness / Efficacy

Zenlo’s detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern. Source: 5-model benchmark, medRxiv MEDRXIV/2026/346284.

Fairness / Equity

Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.

Safety / Reliability

• Supportive-only; not intended as a standalone diagnostic
• Physician authorization required before clinical use
• Deterministic detector is reproducible for inputs: HSCRP, ESR, FERR

Resources

• medRxiv preprint MEDRXIV/2026/346284 — 5-model benchmark (system-level detector evaluation)
• JAMIA Open submission JAMIO-2026-0120 (under review)
• Independent audit harness: github.com/dimashibakov/zenlo-audit — reproducibility manifest, NHANES 2015–2016 cycle, harness commit c10afe8