Prove the swap shows up in the body.
A "non-toxic" cleaner or personal-care line promises lower chemical exposure. Have a cohort switch to it for six weeks and we read the exposure biomarkers — phthalate and paraben metabolites, with the inflammatory response — before and after. A measured drop that stands behind the claim, not a "free-from" sticker.
The claim at stake
"Non-toxic" is a claim about the body, not the bottle. Low-tox positioning promises less of something ending up in you. The only way to show it is to measure what the cohort actually carries — before the switch and after.
A "free-from" sticker
Ingredient-list claims and a clean aesthetic — nothing measured in the body a retailer or regulator can check.
label · not measured
A measured exposure drop
The cohort's own metabolite levels, before and after the switch, read into a per-axis delta with significance.
paired · Δ · p-value
A claim you can defend
Substantiation retail buyers and regulators accept for low-tox positioning — and an R&D baseline for reformulation.
retail · regulatory · R&D
How the engine applies
One switch study in, a signature out. You bring the cohort's before/after exposure panels; the engine reads the exposure axis, computes the paired drop and significance, and returns a Signature Report that backs the claim.
The axis we read
Exposure is measurable in days, not years. Most consumer-product chemicals clear fast, so a six-week switch shows up in the metabolites — these are the markers that move.
Phthalate metabolites
Fragrance and plastic-borne phthalates, measured as urinary metabolites — the headline exposure marker.
MEP · MEHP · MBP
Paraben metabolites
Preservatives common in personal care and cleaners — among the fastest to fall after a switch.
methyl- · propylparaben
Environmental phenols
Bisphenols and antimicrobials that track with packaging and formulation choices.
BPA/BPS · triclosan
Inflammatory readout
The downstream biological response — whether a lower exposure load tracks with lower inflammation.
hs-CRP · oxidative stress
Who this is for
Any brand selling a lower-exposure swap. If the promise is "fewer chemicals in you" — cleaner home, laundry or body care — there's an exposure biomarker that should drop, and a cohort that can prove it.
«Non-toxic home»
Branch Basics
Blueland
Grove Co
Puracy
ATTITUDE
Branch Basics, Blueland, Grove Co, Puracy, ATTITUDE
«Free from the nasties»
Dropps
Molly's Suds
Seventh Generation
Ecover
Dirty Labs
Dropps, Molly's Suds, Seventh Generation, Ecover, Dirty Labs
«Low-tox on your skin»
Beautycounter
Native
Each & Every
Ursa Major
By Humankind
Beautycounter, Native, Each & Every, Ursa Major, By Humankind
Logos shown are market examples of each segment, to illustrate who the application fits — not Zenlo clients or partners, and no endorsement is implied. The fit is the claim type, not the logo.
What this is — and isn't
Evidence for a claim, not a health claim
We measure what moved in a cohort and hand you the trail. We don't manufacture the result, and we don't make medical or safety claims on the product's behalf.
Illustrative application
This page shows how the engine would apply to a household-product switch study.
- No named client or product
- Numbers shown are example endpoints
- The real signature comes from your data
The cohort owns the result
The signature is whatever the panels say — down, flat, or up.
- Paired before/after, with significance
- Drivers named; nothing cherry-picked
- Reproducible from the same inputs
Not a medical claim
A measured exposure shift is evidence, not a diagnosis or a safety guarantee.
- For product substantiation & R&D
- Claims language stays the brand's responsibility
- Zero data retention on model calls
Turn your switch study into a signature.
Send one cohort's before/after exposure panels and we return a Signature Report: the measured exposure drop, with an evidence trail your buyers and regulators can check.