Database
The library behind every signature.
Browse the full catalogue. 101 biomarkers and 15 clinical patterns — each with its own reference page, mapped to the engine and the evidence behind it.
Patterns
15 clinical patterns the engine reads. Filter by validation status or search. Each card opens the pattern's full page — biomarkers, method and evidence.
Insulin resistance
NHANES-validatedInsulin-resistance signal in a cohort's metabolic panel.
Cardiovascular risk
Validation pendingLipid and inflammatory markers associated with atherosclerotic cardiovascular risk.
Inflammation
Validation pendingLaboratory evidence of systemic or chronic inflammatory activity.
Liver stress
Validation pendingElevated liver transaminases and GGT suggesting hepatocellular or cholestatic stress.
Iron deficiency
Validation pendingIron-status profile consistent with depleted stores or functional iron deficiency.
Thyroid dysfunction
Validation pendingAbnormal TSH and free thyroid hormones signaling hypo- or hyperthyroid states.
Vitamin D & calcium
Validation pendingLow vitamin D status and calcium/PTH dysregulation.
Anemia
Validation pendingLow hemoglobin, hematocrit and/or microcytic indices in a CBC.
Kidney stress
Validation pendingCreatinine elevation, BUN abnormality and reduced eGFR suggesting renal impairment.
Metabolic syndrome
NHANES-validatedA cluster of metabolic lab abnormalities (ATP-III-style) from a fasting panel.
Hormonal imbalance (male)
Validation pendingAndrogen, adrenal and anabolic-catabolic signals in a male panel.
Hormonal imbalance (female)
Validation pendingReproductive-axis and adrenal signals in a female panel.
Advanced cardiovascular risk
Validation pendingMarkers of residual cardiovascular risk beyond a basic lipid panel.
Oxidative stress
Validation pendingLab proxies for oxidative and metabolic stress (GGT, uric acid, homocysteine, albumin).
Autoimmune risk
Validation pendingAutoimmune- or inflammatory-associated markers flagged for review.
No patterns match.
Biomarkers
101 biomarkers, catalogued
Filter by category or search by code, name or system. Each tile opens a reference sheet with units and ranges.
No biomarkers match.
Research
The methodology, in the open. Preprints and working papers behind the engine — published here in full.
Multi-Model Clinical Validation of an AI-Powered Biomarker Analysis Framework: A Cross-Vendor Benchmark on 4,018 NHANES Patients
Preprint · medRxivA prompt-based framework flags eight clinical patterns from lab biomarkers, benchmarked across five LLMs from four providers on 4,018 NHANES adults. All five cleared the clinical-grade threshold (mean F1 ≈ 0.865–0.963).
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A Three-Tier Marker Framework with Asymmetric Compound Detection Rules for Metabolic Syndrome Screening: Validation Against Mortality in Pooled NHANES (2007–2016)
Working paper · draftA three-tier marker taxonomy mapped to asymmetric ≥N-of-M rules, validated against all-cause and cardiovascular mortality in 9,245 NHANES adults. The ≥3-of-5 rule tracks mortality where flat any-trigger logic does not.
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See it on your cohort
Send one trial's before/after panels and we return a Signature Report: a measurable profile shift with an evidence trail.