Transparency · CHAI Applied Model Card
Inflammation
CHAI Applied Model Card (v0.1) for the Inflammation pattern in Zenlo Labs. This document is not CHAI-certified or CHAI-endorsed.
Header
Summary
The Inflammation pattern surfaces laboratory evidence of systemic or chronic inflammatory activity in adult panels. A deterministic detector evaluates high-sensitivity CRP, erythrocyte sedimentation rate, and ferritin against pattern-specific thresholds, with sex-aware ferritin cutoffs. Any qualifying elevation fires the pattern. An LLM-assisted narrative explains which inflammatory markers are abnormal and suggests clinical context for physician review. The tool is intended for licensed functional-medicine physicians as supportive clinical decision support — it does not distinguish infection from autoimmune or metabolic inflammation, and it does not replace targeted workup. Outputs prompt physician judgment rather than automated diagnosis.
Uses & Directions
Intended use
Clinical decision support for licensed physicians evaluating inflammatory marker patterns in adult laboratory panels.
Primary users
Licensed functional-medicine physicians and similarly qualified clinicians.
How to use
Interpret flagged results alongside symptoms, medications, acute illness, and follow-up inflammatory or autoimmune testing. Physician authorization required.
Target population
Adults aged 18 and older in the United States.
Out of scope
- Direct patient use without physician oversight
- Pediatric populations
- Standalone diagnosis of specific inflammatory diseases
- Acute infection triage without clinical correlation
Warnings
Clinical risk level
Low — supportive tool; the treating physician retains full clinical judgment and responsibility.
Known limitations
- hs-CRP and ferritin are non-specific; elevations have many causes including infection, obesity, and liver disease.
- Does not differentiate acute versus chronic inflammation.
- Ferritin as an inflammatory marker overlaps semantically with iron-status interpretation.
Validation note
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Trust Ingredients
AI system facts
- Deterministic pattern detector (inflammation) plus Claude Haiku 4.5 for narrative synthesis
- Primary inputs: hs-CRP, ESR, and ferritin from structured laboratory extraction.
- Output: Pattern flag plus narrative on inflammatory marker abnormalities.
Security & compliance
- Anthropic Business Associate Agreement with zero-data-retention configuration
- HIPAA-aligned design; no patient data used for model training
Ongoing maintenance
Versioned, transparent, and reproducible via a public independent audit harness (see Resources).
Transparency
Self-funded development; no third-party sponsor for this pattern card.
Key Metrics
Usefulness / Efficacy
Zenlo’s detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern. Source: 5-model benchmark, medRxiv 10.64898/2026.02.13.26346284.
Fairness / Equity
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Safety / Reliability
- Supportive-only; not intended as a standalone diagnostic
- Physician authorization required before clinical use
- Deterministic detector is reproducible for inputs: HSCRP, ESR, FERR
Resources
Note: The mention or sharing of any examples, products, organizations, or individuals does not indicate any endorsement by the Coalition for Health AI (CHAI). Zenlo Labs is a clinical decision support tool intended exclusively for use by licensed healthcare providers — not a substitute for professional medical judgment, and not intended for direct patient use.
Version v0.1 · Zenlo Research