Prove the supplement moves the marker.
A supplement promises to raise a nutrient or lower a risk. Run a cohort on it for eight to twelve weeks and we read the target nutrient and its downstream markers — omega-3 index, vitamin D, lipids, inflammation — before and after. A measured repletion that stands behind the dose, not a label claim.
The claim at stake
A dose on the label isn't a level in the blood. Bioavailability, form and adherence decide whether a supplement actually moves the marker it targets. The only proof is the cohort's own levels — before and after.
A dose on the label
An RDI figure and a benefit story — no proof it reaches the blood or corrects what it claims to.
label · not measured
A measured repletion
The cohort's target nutrient and downstream markers, before and after, read into a per-axis delta with significance.
paired · Δ · p-value
A claim you can defend
Substantiation retail buyers and practitioners trust — and an R&D baseline for dose, form and bioavailability.
retail · practitioner · R&D
How the engine applies
One trial's panels in, a signature out. You bring the cohort's before/after lab panels; the engine reads the nutrient axis, computes the paired repletion and significance, and returns a Signature Report that backs the dose.
The axis we read
The target nutrient, plus what it's supposed to move. A supplement should raise its direct marker and, if the claim goes further, shift the downstream ones — these are the markers we read.
Omega-3 index
EPA + DHA in red-cell membranes — the direct, slow-moving target of any omega-3 supplement.
EPA · DHA · O3I
Vitamin D (25-OH)
The most common deficiency to correct — a clean before/after repletion story.
25-OH-D
Lipids
Where omega-3 and other supplements are often claimed to act — the lipid response to repletion.
TG · HDL · LDL
Inflammatory readout
Whether repletion tracks with lower systemic inflammation — the claim many supplements make.
hs-CRP
Who this is for
Any brand whose pill is supposed to change a number. If the promise is a raised nutrient or a lowered risk marker, there's a target that should move — and a cohort that can prove it.
«Clinically dosed EPA/DHA»
Nordic Naturals
Carlson
Thorne
Viva Naturals
Barlean's
Nordic Naturals, Carlson, Thorne, Viva Naturals, Barlean's
«Fix the deficiency»
Ritual
Pure Encapsulations
NOW Foods
Garden of Life
MegaFood
Ritual, Pure Encapsulations, NOW Foods, Garden of Life, MegaFood
«Backed by biomarkers»
Momentous
AG1
Seed
Elysium
BIOptimizers
Momentous, AG1, Seed, Elysium, BIOptimizers
Logos shown are market examples of each segment, to illustrate who the application fits — not Zenlo clients or partners, and no endorsement is implied. The fit is the claim type, not the logo.
What this is — and isn't
Evidence for a claim, not a health claim
We measure what moved in a cohort and hand you the trail. We don't manufacture the result, and we don't make medical claims on the product's behalf.
Illustrative application
This page shows how the engine would apply to a supplement trial.
- No named client or product
- Numbers shown are example endpoints
- The real signature comes from your data
The cohort owns the result
The signature is whatever the panels say — up, down, or flat.
- Paired before/after, with significance
- Drivers named; nothing cherry-picked
- Reproducible from the same inputs
Not a medical claim
A measured repletion is evidence, not a diagnosis or a treatment claim.
- For product substantiation & R&D
- Claims language stays the brand's responsibility
- Zero data retention on model calls
Turn your trial into a signature.
Send one trial's before/after panels and we return a Signature Report: the measured repletion, with an evidence trail your buyers and practitioners can check.